Why are PDE5 inhibitors contraindicated with nitrates?

Why are PDE5 inhibitors contraindicated with nitrates?

The phosphodiesterase-5 (PDE5) inhibitor sildenafil is approved by the US Food and Drug Administration for the treatment of erectile dysfunction. Sildenafil is contraindicated in combination with nitrates due to the risk for a pharmacodynamic drug interaction that can result in severe hypotension and death.

Why is sildenafil not given with nitrates?

Sildenafil is absolutely contraindicated in patients taking any long-acting nitrates or using short-acting nitrates because of the risk of developing potentially life-threatening hypotension.

What meds are contraindicated with PDE5 inhibitors?

Contraindications. PDE5 inhibitors are contraindicated within 24 hours (or 48 hours with tadalafil) of taking alpha-blockers, soluble guanylate cyclase stimulators, or nitrate medications such as isosorbide mononitrate or isosorbide dinitrate.

How Does sildenafil interact with nitroglycerin?

Using sildenafil together with nitroglycerin is not recommended. Combining these medications may cause blood pressure to fall excessively, which can lead to cardiovascular collapse.

When taking a PDE 5 inhibitor concomitant use of which medication must be avoided?

Because of their extensive CYP3A4 metabolism, PDE5 inhibitors carry a risk of interacting with potent CYP3A4 inhibitors and inducers. The concomitant use of potent CYP3A4 inhibitors increases plasma concentrations of sildenafil.

Which medication is most likely to interact with a PDE5 inhibitor?

PDE5 inhibitors can interact with nitrates — a class of prescription medications that are used to treat heart conditions such as angina. Using a PDE5 inhibitor at the same time as a nitrate can cause a sudden, significant and potentially dangerous drop in your blood pressure.

What is the major drug interaction between phosphodiesterase inhibitors such as sildenafil and nitrates?

PDE5 inhibitors such as Viagra and nitrates both have the same effects on the diameter of your blood vessels. When used together, the interaction between these medications can cause your blood pressure to drop too low, affecting your consciousness and heart health.

Why is Viagra bad for the heart?

Though Viagra is intended to work on the arteries in the penis, its effects are systemic. All arteries in the body product nitric oxide, so Viagra could potentially trigger vasodilation in other arteries, which could cause a temporary drop in blood pressure by 5 to 8 mmHg.

What do phosphodiesterase inhibitors do?

What is a phosphodiesterase inhibitor? Phosphodiesterase inhibitors are a class of medications that promote blood vessel dilation (vasodilation) and smooth muscle relaxation in certain parts of the body, such as the heart, lungs, and genitals.

Is sildenafil a phosphodiesterase 5 inhibitor?

Sildenafil, vardenafil, tadalafil, and avanafil are classified as PDE5 inhibitors and are indicated for the treatment of men with ED. Sildenafil, the first PDE5 inhibitor, was introduced in 1998. More than 20 million men were treated with sildenafil in its first 6 years on the market.

Why is nitroglycerin contraindicated in patients that have taken a phosphodiesterase inhibitor for Ed?

Because both PDE5Is and nitrates increase cGMP, coadministration can generate excess accumulation of cGMP and can trigger marked vasodilation and severe hypotension.

How does phosphodiesterase 5 inhibitors work?

PDE5 inhibitors block PDE5, an enzyme in the walls of blood vessels. Blocking PDE5 causes blood vessels to relax, increasing blood flow to certain areas of the body. This effect means that they can help manage conditions such as erectile dysfunction and pulmonary hypertension.