What is the hematological disorder benefited by splenectomy?

What is the hematological disorder benefited by splenectomy?

Patients with various hematologic disorders may benefit from splenectomy. Splenomegaly (see the image below) is observed in conditions such as idiopathic (immune) thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), and hereditary spherocytosis.

How does a splenectomy affect anemia?

cases of acquired hemolytic anemia splenectomy will remove the major site of red cell destruction and in turn increase the hemoglobin concentration and abolish the need for an accelerated rate of red cell production.

What is the most common complication of splenectomy?

Infections, particularly pulmonary and abdominal sepsis, constitute the majority of the complications. The mortality rate from postoperative sepsis is substantial. Atelectasis, pancreatitis/fistula, pulmonary embolism and bleeding at the operative site are also relatively common occurrences following splenic removal.

What are the side effects of a splenectomy?

But as with any surgery, splenectomy carries the potential risk of complications, including:

  • Bleeding.
  • Blood clots.
  • Infection.
  • Injury to nearby organs, including your stomach, pancreas and colon.

What happens after a dog has a splenectomy?

Your pet may be able to go home the same day or may require several days of hospitalization. When discharged, full recovery should occur in two weeks. The diseased spleen and its large blood clots may weigh up to 10 lbs in a large dog and therefore, pets will appear substantially thinner after surgery.

Does the spleen affect iron?

Extra iron that is not immediately needed to make new blood cells is normally stored in the liver, spleen, and bone marrow. This excess iron can lead to injury of the organs in which it is deposited. What are the symptoms of iron overload?

What is the most common early complication of open splenectomy?

These are reported with both open and laparoscopic splenectomy. Early postoperative complications include pulmonary complications (atelectasis to pneumonia), subphrenic abscess, ileus, portal vein thrombosis, thrombocytosis, thrombotic complications, and wound complications (hematomas, seromas, and wound infections).

Why does splenectomy increased risk of infection?

The factors responsible for an increased incidence of infection and propensity for severity following a splenectomy include insufficient opsonizing filter function of the spleen, delayed and impaired production of immunoglobulin (Ig), lack of splenic macrophages, and minimal tufts production [5].

Why does a splenectomy lead to an increased risk of septicemia?

The spleen is a reticuloendothelial organ that facilitates opsonization and phagocytosis of pathogens, in addition to cellular maintenance. Splenectomy is associated with an impairment in immunoglobulin production, antibody-mediated clearance, and phagocytosis, leading to an increased risk of infection and sepsis.