What is follicular lymphoma 3b?
FL grade 3B was defined according to the WHO classification2 as a follicular lymphoma, that is, a neoplasm derived from follicle center B cells, with at least a partially follicular pattern and with neoplastic follicles composed of solid sheets of centroblasts without residual centrocytes.
How do you treat Grade 3b follicular lymphoma?
I generally think of follicular lymphoma grade 3b as a lymphoma that really acts and should be treated as an aggressive lymphoma. So, grade 3b, I generally treat as a large-cell lymphoma, and I think about that as kind of a transformed follicular. Generally, I treat them with combined chemotherapy with rituximab.
Is follicular B cell lymphoma curable?
Follicular lymphoma is usually not considered to be curable, but more of a chronic disease. Patients can live for many years with this form of lymphoma.
How many grades of follicular lymphoma are there?
Follicular lymphoma is usually slow growing and called a low grade lymphoma. Doctors might further subdivide follicular lymphoma into 3 grades. These are 1, 2, and 3.
Is Stage 3 follicular lymphoma curable?
For people with stage II, III, or IV disease (table 1), the average survival is greater than 20 years. Despite its slow-growing nature, it is unclear whether most cases of follicular lymphoma can be cured with currently available therapies.
Is grade 3 follicular lymphoma curable?
No definitive curability could be seen yet with either grade 3a or grade 3b. The Working Formulation classified FLCL into an intermediate grade NHL together with diffuse large B cell non-Hodgkin’s lymphoma (DLBCL).
What is the prognosis for follicular lymphoma?
The five-year survival rate for follicular lymphoma is between 80 and 90 percent, which means at least 80 to 90 percent of patients diagnosed with follicular lymphoma can live for at least five years after the diagnosis. Half of the patients diagnosed with this type of cancer can live for approximately 10 to 12 years.
When should you start treatment for follicular lymphoma?
Active treatment is started if the patient begins to develop lymphoma-related symptoms or there are signs that the disease is progressing based on testing during follow-up visits. FL is generally very responsive to radiation and chemotherapy.
What is the cause of follicular lymphoma?
It can develop at any age, but it is more common in people over 60. In most cases, there is no known cause for follicular lymphoma. Some genetic changes are common in follicular lymphoma, but scientists don’t know what causes them. There is not normally any family history of follicular lymphoma.