What is CD24 a marker for?

What is CD24 a marker for?

CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways.

What is CD127?

CD127 is found on normal B cell precursors but not on mature B lymphocytes. It is also expressed by thymocytes, the majority of peripheral T lymphocytes, a subset of monocytes and a subset of CD34+ cells. CD127 is a useful marker for identifying memory and effector T cells.

What are CD24 cells?

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.

What is CD24 MADE OF?

CD24 is a small but extensively glycosylated protein linked to the cell surface by means of a glycosyl-phosphatidylinositol anchor. In this study we found that CD24 is present in membrane vesicles characterized as exosomes that were isolated from the urine of normal individuals.

How does T cell exhaustion happen?

T cell exhaustion is a progressive loss of effector function due to prolonged antigen stimulation, characteristic of chronic infections and cancer. In addition to continuous antigen stimulation, antigen presenting cells and cytokines present in the microenvironment can also contribute to this exhausted phenotype.

What does CD24 stand for?

View/Edit Human. Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene. CD24 is a cell adhesion molecule .

Is CD24 gene expression high in tumors?

Using data from The Cancer Genome Atlas program and NCI’s TARGET program, the Stanford team found that expression of the CD24 gene was higher in tumors than in the corresponding normal tissue. CD24 expression was elevated most dramatically in ovarian cancer.

Is CD24 the new “Don’t Eat Me” protein?

To find out whether CD24 is a new “don’t eat me” protein, the researchers used a gene-editing tool to remove the gene that makes the CD24 protein from a lab-grown human breast cancer cell line. They then mixed the CD24-deficient cells and normal breast cancer cells with human macrophages in lab dishes.

Does CD24 have a future in cancer treatment?

However, the character of CD24 remains to be intriguing because there are still opposite voices about the impact of CD24 on tumors. In preclinical studies, CD24 target therapies, including monoclonal antibodies, target silencing by RNA interference and immunotherapy, have shown us brighten futures on the anti-tumor application.