What is bone plasmacytoma?
Solitary plasmacytoma of bone (SPB, also called osseous plasmacytoma) is a localized tumor in the bone comprised of a single clone of plasma cells in the absence of other features of MM (ie, anemia, hypercalcemia, renal insufficiency, or multiple lytic bone lesions) [6,7].
Is plasmacytoma a bone cancer?
Solitary bone plasmacytoma is a bone tumor that arises from plasma cells. Plasmacytomas can occur in any bone, but they are most common in the spine.
What causes plasmacytoma?
What is the cause of plasmacytoma? It is not known what causes plasmacytoma. Radiation, industrial solvents and airborne toxins have been identified as possible risk factors.
Is plasmacytoma a solid tumor?
SPBs occur as lytic lesions within the axial skeleton and extramedullary plasmacytomas most often occur in the upper respiratory tract (85%), but can occur in any soft tissue. Approximately half of all cases produce paraproteinemia….
|Specialty||Hematology and oncology|
Where are plasmacytoma found?
A plasmacytoma can arise in any part of the body. A solitary bone plasmacytoma (SBP) arises from the plasma cells located in the bone marrow, whereas an extramedullary plasmacytoma (EMP) is thought to arise from plasma cells located in mucosal surfaces.
Are Plasmacytomas fast growing?
Solitary bone plasmacytoma (SBP) progresses to multiple myeloma at a rate of 65-84% at 10 years and 65-100% at 15 years. The median onset of conversion to multiple myeloma is 2-5 years with a 10-year disease-free survival rate of 15-46%.
How do you treat plasmacytoma?
Treatment of extramedullary plasmacytoma may include the following:
- Radiation therapy to the tumor and nearby lymph nodes.
- Surgery, usually followed by radiation therapy.
- Watchful waiting after initial treatment, followed by radiation therapy, surgery, or chemotherapy if the tumor grows or causes signs or symptoms.
What does Paraproteinemia mean?
What is Paraproteinemia? Paraproteinemia, also known as monoclonal gammopathy, is characterized by the presence of excessive amounts of paraproteins in the blood. Paraproteins are immunoglobulin proteins that are produced by a clone of plasma cells in the bone marrow. These proteins often cause damage to the kidneys.
How long can you live with plasmacytoma?
Solitary bone plasmacytoma (SBP) progresses to multiple myeloma at a rate of 65-84% at 10 years and 65-100% at 15 years. The median onset of conversion to multiple myeloma is 2-5 years with a 10-year disease-free survival rate of 15-46%. The overall median survival time is 10 years.
What is the prognosis of solitary bone plasmacytoma (SBP)?
Approximately 30% of patients with solitary bone plasmacytoma (SBP) remain disease-free for several years; some of these patients may be cured. Patients with the best prognosis are those in whom the monoclonal protein disappears by 1 year after radiotherapy .
What type of cancer is plasmacytoma?
Plasmacytoma is a tumor of plasma cells. The cells are identical to those seen in multiple myeloma, but they form discrete masses of cells in the skeleton (solitary plasmacytoma of bone; SPB) or in soft tissues (extramedullary plasmacytoma; EP).
What is the prognosis of extramedullary plasmacytoma (EMP)?
Patients with EMP have a 5-year survival rate of about 82% and 10-year disease-specific survival rate greater than 50%. [ 11] The rate of progression to multiple myeloma is lower than in SBP, ranging from 11% to 30% at 10 years. [ 14]
What causes solitary plasmacytoma?
Causes of Solitary plasmacytoma. The specific cause is unknown but risk factors appear to be: Exposure to radiation. Family history of the condition. Exposure to carcinogens. more causes…».