What is Bombay phenotype an example of?
There are many examples of epistasis. One of the first to be described in humans is the Bombay phenotype , involving the ABO blood group system. Individuals with this phenotype lack a protein called the H antigen (geno-type hh), which is used to form A and B antigens.
What is Bombay phenotype in genetics?
Bombay phenotype occurs in individuals who have inherited two recessive alleles of the H gene (i.e.: their genotype is hh).
What is the Bombay genotype?
Bombay phenotype Serum contains anti-H. Genotype: h/h se/se.
Is Bombay phenotype recessive epistasis?
The Bombay phenotype is an example of recessive epistasis in humans. A woman who has type AB blood and is heterogygous for the H gene marries a man whos genotype is I^AI^B hh.
What type of epistasis is Bombay phenotype?
A rare human variant of the ABO blood group system (first discovered in Bombay, India) that does not have A, B, or O antigens. This is a classical case of recessive epistasis in human genetics, because without the product of allele H, the products of the ABO locus cannot be formed.
How common is Bombay phenotype?
Around 179 persons in India with a frequency of 1 in 10,000 have “Bombay Blood group”. A high level of consanguinity present among the parents of the Bombay phenotype. The classic Bombay phenotype has been reported in those of Indian descendent. It is quite rare in Caucasian with an incidence of 1 in 250,000.
What antibodies are formed by a Bombay phenotype?
In keeping with the way other ABO system antibodies are formed, Bombay individuals make anti-A, anti-B, and anti-A,B, exactly like others that are group O. However, they also make a strong and very dangerous anti-H.
What is the meaning of Bombay blood group?
The Bombay blood group is a rare blood group, phenotypes of this group lacking H antigen on the red cell membrane and have anti-H in the serum. It fails to express any A, B or H antigen on their red cells or other tissues. Around 179 persons in India with a frequency of 1 in 10,000 have “Bombay Blood group”.
How are mitochondrial genes typically inherited?
You inherited your mitochondrial DNA from your mother, who inherited hers from her mother and so forth. Maternal inheritance also gave rise to the idea that there exists a “Mitochondrial Eve,” a woman from whom all living humans inherited their mitochondrial DNA.
What is an example of an environmental effect on phenotype?
Environment Can Impact Phenotype Environmental factors such as diet, temperature, oxygen levels, humidity, light cycles, and the presence of mutagens can all impact which of an animal’s genes are expressed, which ultimately affects the animal’s phenotype.