What is a DNA binding Vesicant?

What is a DNA binding Vesicant?

DNA binding vesicant drugs such as amsacrine, dactinomycin, daunorubicin, doxorubicin, epirubicin, idarubicin, mitomycin: have a direct effect on the cell in healthy tissue when they are extravasated. cause progressive tissue destruction as they bind to cellular DNA and recycle locally.

Is idarubicin a DNA binding Vesicant?

Examples of DNA-binding vesicants include anthracyclines (daunoru- bicin, doxorubicin, epirubicin, idarubicin), dactinomycin, mech- lorethamine (nitrogen mustard), mitomycin, and mitoxantrone.

Is carboplatin a vesicant?

Carboplatin is a platinum chemotherapeutic agent commonly used in veterinary oncology that is currently classified as an irritant to local tissues when extravasated. To the authors’ knowledge, there are no reports of vesicant injuries associated with carboplatin administration reported in the veterinary literature.

Is methylene blue a vesicant?

May be diluted (in D5W only) prior to administration to avoid pain on injection. Vesicant; ensure proper needle or catheter placement prior to and during infusion; avoid extravasation.

Can Remdesivir be diluted with saline?

Remdesivir for injection (100 mg lyophilized powder) must be reconstituted with Sterile Water for Injection and diluted in 0.9% saline. Remdesivir injection (5 mg/mL solution) must be diluted in 0.9% saline.

Is Epinephrine a vesicant?

It should be administered ONLY by clinicians trained and experienced in dose titration of intravenous epinephrine using continuous noninvasive electronic monitoring of heart rate and blood pressure. Epinephrine is an ischemia-causing agent and vesicant. Monitor infusion site for extravasation.

Is vancomycin an irritant or a vesicant?

Vancomycin is acidic (pH 2.5–4.0) and hyperosmolar (328 mOsm/L), which may make it a vesicant when administered through a peripheral line. Bohm and Wong describe bullous dermatitis as a result of vancomycin extravasation.

Is remdesivir a vesicant or irritant?

One of the most common adverse events with remdesivir use is skin rashes. The chemotherapeutic drugs are commonly known for their vesicant effect causing infusion site reactions. The severe type of reaction occurs due to drug extravasation which can occur immediately or may be delayed up to 6–12 hours.