What does HOXA10 do?
Hoxa10/HOXA10 function is essential for normal uterine embryogenesis and regulation of the menstrual cycle, because it regulates a variety of downstream genes, including cell adhesion molecules, signal transduction factors, and metabolic mediators.
Are promoters regulatory proteins?
A promoter is induced in response to changes in abundance or conformation of regulatory proteins in a cell, which enable activating transcription factors to recruit RNA polymerase.
What are homeobox genes?
Homeobox genes are master developmental control genes that act at the top of genetic hierarchies regulating aspects of morphogenesis and cell differentiation in animals. These genes contain a common sequence element of 180 bp, the homeobox, which was first discovered in the fruit fly Drosophila.
What are homeobox transcription factors?
Homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. These family members are characterized by a helix-turn-helix DNA-binding motif known as the homeodomain (encoded by the 180 bp homeobox sequence element).
Is promoter a regulatory sequence?
The regulatory sequences include the promoter region together with enhancer elements. Every gene has a promoter, which is the binding site for the basal transcriptional apparatus – RNA polymerase and its co-factors.
How do you identify a promoter sequence?
To find the promoter region, use Map Viewer to locate the gene within a chromosomal context. Then increase the value of the coordinates that surround the gene to a larger sequence that includes the promoter.
What is a homeobox protein?
Homeobox proteins are a large family of transcription factors (TFs) that contain a highly conserved DNA-binding domain of 60 amino acids known as the homeodomain.
Is a promoter a protein?
The promoter region is the sequence typically referred to that’s right upstream or right next to where a gene is about to be transcribed. It’s the region where certain regulatory elements will bind; these are proteins that will bind to help RNA get transcribed.
What is hohoxa10 and why is it important?
HOXA10 is overexpressed in oral squamous cell carcinoma (OSCC) and its expression is functionally associated with several important biological processes related to oral tumorigenesis, such as proliferation, migration and invasion.
How do Hoxa10 and CDX4 interact with SIRT2?
“HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells.” “Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10.” Cited for: INTERACTION WITH SIRT2. “HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells.”
Is HOXA10 gene involved in the pathophysiology of endometriosis?
Study shows that the HOXA10 gene, as a homeodomain transcription factor, is dynamically expressed in the endometrium, and peak expression occurs in the secretory phase of the menstrual cycle. Study focused on the epigenetic role of the HOXA10 gene related to clinical pathophysiology of endometriosis.
What is the role of HOXA10 in the development of bladder cancer?
HOXA10 promotes the development of bladder cancer through regulating FOSL1. Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemia. Nur77 promotes embryo adhesion by transcriptionally regulating HOXA10 expression. Laparoscopic Ovarian Drilling Improves Endometrial Homeobox Gene Expression in PCOS.