What causes Hypomelanosis of Ito?

What causes Hypomelanosis of Ito?

The exact cause of hypomelanosis of Ito is unknown. Many cases are associated with genetic mosaicism and sporadic gene mutations. Genetic mosaicism is the term for individuals who have two distinct cell lines in the body that developed because of a gene mutation that occurred during embryonic development.

Is Hypomelanosis treatable?

Idiopathic guttate hypomelanosis is a common acquired skin condition characterized by multiple discrete, round, porcelain-white macules on the extensor aspects of the extremities in the elderly population. Most patients are reassured of the benign nature of the condition and no treatment is recommended.

Does pigmentary mosaicism go away?

Pigmentary mosaicism is a permanent color change in the skin. We are not able to change the genetic material to make the skin color the same.

What is Hypomelanosis of Ito syndrome genetic mosaic?

Hypomelanosis of Ito is a pigmentary mosaicism characterized by a clone of skin cells with decreased ability to produce pigment. The clinical pattern is characterized by hypopigmented streaks and whorls running along the lines of Blaschko, characteristically involving more than two body segments.

How is Hypomelanosis treated?

Medical therapy for idiopathic guttate hypomelanosis includes corticosteroids, either topical or intralesional, and retinoids, typically topical tretinoin.

How do you get rid of idiopathic guttate Hypomelanosis spots?

What is the treatment for idiopathic guttate hypomelanosis?

  1. Cryotherapy β€” 5 second, single session, repigmentation visible by 4 months.
  2. Topical treatments β€” topical steroid, tacrolimus, topical retinoids.
  3. Procedural treatments β€” chemical peel, excimer laser, skin grafting.

What causes pigmentary mosaicism?

Pigmentary mosaicism is nowadays recognized as a pigmentary disorder caused by somatic chromosomal abnormalities disrupting or accelerating the function of pigmentary genes. Affected individuals with pigmentary mosaicism commonly have multiple congenital abnormalities, developmental delays and/or mental retardation.

How do you treat Hypopigmented skin?

Hypopigmentation is a condition in which the skin is lighter in color than normal. Treating hypopigmentation may involve the use of topical corticosteroids or tars, light or laser treatment, or surgical skin grafting. Melanin is the substance that gives skin its color or pigment.

How do you fix Hypopigmented scars?

Hypopigmented scars are often considerably lighter than surrounding skin and tend to be permanent. Today’s treatment options, including scar excision, laser treatment, phototherapy and medical tattooing, fall short of reliably restoring color that matches the surrounding skin.

How do you treat hypopigmentation naturally?


  1. Use a Strong Sunblock.
  2. Gentle Exfoliation.
  3. Massage in a Natural Scar Treatment Oil.
  4. Aloe Vera.
  5. Green Tea.
  6. Liquorice Extract.
  7. Vitamin C.
  8. Apple Cider Vinegar.