How is ORENCIA dosed?
Intravenous Dosing Regimen Administer ORENCIA as a 30-minute intravenous infusion utilizing the weight range-based dosing specified in Table 1. Following the initial intravenous administration, administer an intravenous infusion at 2 and 4 weeks and every 4 weeks thereafter.
How often do you inject ORENCIA?
ORENCIA should be administered weekly at a dose of 125 mg by subcutaneous (SC) injection without the need for an intravenous (IV) loading dose.
How long does it take for ORENCIA to work for RA?
How long does it take for ORENCIA to work? It’s important to know that it may take a little while for you to respond to your new treatment. Many people started feeling better in about 3 to 6 months. Individual results may vary.
What is the half life of ORENCIA?
Healthy Adults and Adult RA – Intravenous Administration
| PK Parameter | Healthy Subjects (After 10 mg/kg Single Dose) n=13 |
|---|---|
| Peak Concentration (Cmax) [mcg/mL] | 292 (175-427) |
| Terminal half-life (t1/2) [days] | 16.7 (12-23) |
| Systemic clearance (CL) [mL/h/kg] | 0.23 (0.16-0.30) |
| Volume of distribution (Vss) [L/kg] | 0.09 (0.06-0.13) |
Can you overdose on ORENCIA?
Orencia Overdose If you take too much Orencia, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. If Orencia is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur.
How do you reconstitute ORENCIA?
The ORENCIA powder in each vial must be reconstituted with 10 mL of Sterile Water for Injection, USP, using only the silicone-free disposable syringe provided with each vial and an 18- to 21-gauge needle. After reconstitution, the concentration of abatacept in the vial will be 25 mg/mL.
Can ORENCIA be self administered?
self-administer. For your patients who prefer to self-inject, ORENCIA offers 2 subcutaneous administration options via self-injection devices. ORENCIA prefilled syringes are intended for: Subcutaneous use only and are not intended for intravenous infusion.
How will I feel after Orencia infusion?
Injection-site reactions are more common when Orencia is given by subcutaneous injection than by infusion. These side effects can be mild to moderate and may include: pain. swelling.
Does Orencia make you gain weight?
During clinical studies, weight gain wasn’t a side effect in people taking Orencia. If you’re concerned about weight gain while you’re using Orencia, talk with your doctor. In clinical studies, hair loss wasn’t a side effect in people taking Orencia.
Can you drink on Orencia?
Alcohol may affect how some drugs work. But it doesn’t interact with Orencia. Talk with your doctor about the safety of drinking alcohol while you’re using Orencia.